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Cellosaurus T47D-E2J (CVCL_HG14)

[Text version]
Cell line name T47D-E2J
Synonyms T47D E2J; E2J
Accession CVCL_HG14
Resource Identification Initiative To cite this cell line use: T47D-E2J (RRID:CVCL_HG14)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:4203; GCNT1.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu194Phe (c.580C>T); ClinVar=VCV000127817; Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0553 (T-47D)
Children:
CVCL_HG16 (T47D-StN)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
Publications

PubMed=11118434; DOI=10.1074/jbc.M006523200
Martin Dalziel, Caroline Whitehouse, Ian McFarlane, Inka Brockhausen, Stephen Gschmeissner, Tilo Schwientek, Henrik Clausen, Joy M. Burchell, Joyce Taylor-Papadimitriou;
The relative activities of the C2GnT1 and ST3Gal-I glycosyltransferases determine O-glycan structure and expression of a tumor-associated epitope on MUC1.
J. Biol. Chem. 276:11007-11015(2001)

PubMed=16319059; DOI=10.1074/jbc.M511826200
Robert Sewell, Malin Backstrom, Martin Dalziel, Stephen Gschmeissner, Hasse Karlsson, Thomas Noll, Jochem Gatgens, Henrik Clausen, Gunnar C. Hansson, Joy M. Burchell, Joyce Taylor-Papadimitriou;
The ST6GalNAc-I sialyltransferase localizes throughout the Golgi and is responsible for the synthesis of the tumor-associated sialyl-Tn O-glycan in human breast cancer.
J. Biol. Chem. 281:3586-3594(2006)

Cross-references
Cell line collections (Providers) CancerTools; 153169
Ximbio; 153169
Cell line databases/resources cancercelllines; CVCL_HG14
Encyclopedic resources Wikidata; Q54971560
Entry history
Entry creation01-Dec-2016
Last entry update14-Aug-2025
Version number15