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Cellosaurus S_M6R1 (CVCL_HG09)

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Cell line name S_M6R1
Accession CVCL_HG09
Resource Identification Initiative To cite this cell line use: S_M6R1 (RRID:CVCL_HG09)
Comments Population: African American.
Selected for resistance to: ChEBI; CHEBI_134602; MI-63.
Derived from site: In situ; Bone, femur; UBERON=UBERON_0000981.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gln61His (c.183A>T); ClinVar=VCV000045117; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1697 (SJSA-1)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
Publications

PubMed=27323823; DOI=10.18632/oncotarget.10073; PMCID=PMC5216791
Catherine J. Drummond, Arman Esfandiari, Jun-Feng Liu, Xiao-Hong Lu, Claire Hutton, Jennifer Jackson, Karim Bennaceur, Qing Xu, Aditya Rao Makimanejavali, Fabio Del Bello, Alessandro Piergentili ...Show all 15 authors... , David R. Newell, Ian Robert Hardcastle, Roger J. Griffin, John Lunec; Show fewer authors
TP53 mutant MDM2-amplified cell lines selected for resistance to MDM2-p53 binding antagonists retain sensitivity to ionizing radiation.
Oncotarget 7:46203-46218(2016)

Cross-references
Cell line collections (Providers) CancerTools; 152839
Ximbio; 152839
Cell line databases/resources cancercelllines; CVCL_HG09
Encyclopedic resources Wikidata; Q54951555
Entry history
Entry creation01-Dec-2016
Last entry update19-Dec-2024
Version number16