| Cell line name |
HCT 116 ADAM17 |
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| Synonyms |
HCT116 ADAM17 |
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| Accession |
CVCL_HG03 |
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| Resource Identification Initiative |
To cite this cell line use: HCT 116 ADAM17 (RRID:CVCL_HG03) |
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| Comments |
Transfected with: MGI; MGI:1096335; Adam17.
Derived from sampling site: Colon. |
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| Sequence variations |
- Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 1101; BRCA2; Simple; p.Ile2675Aspfs*6 (c.8021dupA) (c.8021_8022insA); ClinVar=VCV000267050; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Colon carcinoma (NCIt: C4910) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0291 (HCT 116) |
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| Sex of cell |
Male |
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| Age at sampling |
48Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=20570921; DOI=10.1158/1078-0432.CCR-10-0014
Kyula J.N., van Schaeybroeck S., Doherty J., Fenning C.S., Longley D.B., Johnston P.G.
Chemotherapy-induced activation of ADAM-17: a novel mechanism of drug resistance in colorectal cancer.
Clin. Cancer Res. 16:3378-3389(2010) |
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| Cross-references |
|---|
| Cell line collections |
CancerTools; 153209
Ximbio; 153209
|
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| Encyclopedic resources |
Wikidata; Q54881907
|
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| Entry history |
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| Entry creation | 01-Dec-2016 |
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| Last entry update | 21-Mar-2023 |
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| Version number | 11 |
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