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Cellosaurus Jurkat-FADD-/- (CVCL_HF44)

[Text version]
Cell line name Jurkat-FADD-/-
Synonyms E1
Accession CVCL_HF44
Resource Identification Initiative To cite this cell line use: Jurkat-FADD-/- (RRID:CVCL_HF44)
Comments Population: Caucasian.
Transformant: ChEBI; CHEBI_23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1061 (Jurkat clone A3)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): PubMed=15637111

Markers:
AmelogeninX
CSF1PO11,12
D3S135815,17
D5S8189
D7S8208,9.3
D8S117912,14
D13S3178,11
D16S53910,11
D18S5113,22
D21S1131.2,33.2
FGA19,22
Penta D11
Penta E10,12
TH016,9.3
TPOX8,10
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=10616904
Peter Juo, Michele Sue-Ann Woo, Calvin Jay Kuo, Paola Signorelli, Hans-Peter Biemann, Yusuf A. Hannun, John Blenis;
FADD is required for multiple signaling events downstream of the receptor Fas.
Cell Growth Differ. 10:797-804(1999)

PubMed=15637111; DOI=10.1096/fj.04-3062fje
Walther Parson, Romana Kirchebner, Roswitha Muhlmann, Kathrin Renner, Anita Kofler, Stefan Schmidt, Reinhard Kofler;
Cancer cell line identification by short tandem repeat profiling: power and limitations.
FASEB J. 19:434-436(2005)

Cross-references
Cell line databases/resources cancercelllines; CVCL_HF44
Encyclopedic resources Wikidata; Q54899156
Entry history
Entry creation01-Dec-2016
Last entry update19-Dec-2024
Version number17