| Cell line name |
RKO SLC2A1(-/-) |
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| Synonyms |
GLUT1 (-/-) RKO |
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| Accession |
CVCL_HE24 |
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| Resource Identification Initiative |
To cite this cell line use: RKO SLC2A1(-/-) (RRID:CVCL_HE24) |
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| Comments |
Knockout cell: Method=Homologous recombination; HGNC; HGNC:11005; SLC2A1.
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
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| Sequence variations |
- Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Leu452Pro (c.1355T>C); ClinVar=VCV000930524; Zygosity=Heterozygous (from parent cell line).
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| Disease |
Colon carcinoma (NCIt: C4910) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0504 (RKO) |
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| Sex of cell |
Sex unspecified |
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| Age at sampling |
Age unspecified |
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| Category |
Cancer cell line |
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| Publications | PubMed=19661383; DOI=10.1126/science.1174229; PMCID=PMC2820374
Jiyeon Yun, Carlo Rago, Ian Cheong, Raymond Pagliarini, Philipp Angenendt, Harith Rajagopalan, Kerstin Schmidt, James K.V. Willson, Sanford David Markowitz, Shi-Bin Zhou, Luis Alberto Diaz Jr. ...Show all 16 authors... , Victor E. Velculescu, Christoph Lengauer, Kenneth Wayne Kinzler, Bert Vogelstein, Nickolas Papadopoulos; Show fewer authors
Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells.
Science 325:1555-1559(2009) |
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| Cross-references |
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| Cell line collections (Providers) |
Horizon_Discovery; HD+R05-011
|
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| Cell line databases/resources |
cancercelllines; CVCL_HE24
|
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| Encyclopedic resources |
Wikidata; Q54950554
|
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| Entry history |
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| Entry creation | 01-Dec-2016 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 11 |
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