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Cellosaurus RKO MIR21(-/-) (CVCL_HE23)

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Cell line name RKO MIR21(-/-)
Synonyms MIR21 (-/-) RKO; RKO miR-21 KO
Accession CVCL_HE23
Resource Identification Initiative To cite this cell line use: RKO MIR21(-/-) (RRID:CVCL_HE23)
Comments Knockout cell: Method=Homologous recombination; HGNC; HGNC:31586; MIR21.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Leu452Pro (c.1355T>C); ClinVar=VCV000930524; Zygosity=Heterozygous (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0504 (RKO)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=19826040; DOI=10.1158/0008-5472.CAN-09-1996; PMCID=PMC2763324
Peng Wang, Fang-Dong Zou, Xiao-Dong Zhang, Hua Li, Austin M. Dulak, Robert J. Tomko Jr., John Stephen Lazo, Zheng-He Wang, Lin Zhang, Jian Yu;
microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells.
Cancer Res. 69:8157-8165(2009)

Cross-references
Cell line collections (Providers) Horizon_Discovery; HD+R05-013
Cell line databases/resources cancercelllines; CVCL_HE23
Encyclopedic resources Wikidata; Q54950553
Entry history
Entry creation01-Dec-2016
Last entry update19-Dec-2024
Version number11