| Cell line name |
RKO FANCG(+/-) |
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| Synonyms |
FANCG (+/-) RKO |
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| Accession |
CVCL_HE21 |
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| Resource Identification Initiative |
To cite this cell line use: RKO FANCG(+/-) (RRID:CVCL_HE21) |
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| Comments |
Knockout cell: Method=Homologous recombination; HGNC; HGNC:3588; FANCG (Note=1 of 2 alleles).
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
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| Sequence variations |
- Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Leu452Pro (c.1355T>C); ClinVar=VCV000930524; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Colon carcinoma (NCIt: C4910) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0504 (RKO) |
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| Sex of cell |
Sex unspecified |
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| Age at sampling |
Age unspecified |
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| Category |
Cancer cell line |
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| Publications | PubMed=16762635; DOI=10.1053/j.gastro.2006.03.016
Eike Gallmeier, Eric S. Calhoun, Carlo Rago, Jonathan R. Brody, Steven C. Cunningham, Tomas Hucl, Myriam Gorospe, Manu Kohli, Christoph Lengauer, Scott E. Kern;
Targeted disruption of FANCC and FANCG in human cancer provides a preclinical model for specific therapeutic options.
Gastroenterology 130:2145-2154(2006) |
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| Cross-references |
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| Cell line collections (Providers) |
Horizon_Discovery; HD+R05-002
|
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| Cell line databases/resources |
cancercelllines; CVCL_HE21
|
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| Encyclopedic resources |
Wikidata; Q54950551
|
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| Entry history |
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| Entry creation | 01-Dec-2016 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 12 |
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