Cellosaurus logo
expasy logo

Cellosaurus RKO FANCC(-/-/-) (CVCL_HE20)

[Text][XML][JSON]
Cell line name RKO FANCC(-/-/-)
Synonyms FANCC (-/-/-) RKO
Accession CVCL_HE20
Resource Identification Initiative To cite this cell line use: RKO FANCC(-/-/-) (RRID:CVCL_HE20)
Comments Characteristics: RKO carries a stable triplication of the FANCC gene.
Knockout cell: Method=Homologous recombination; HGNC; HGNC:3584; FANCC.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Leu452Pro (c.1355T>C); ClinVar=VCV000930524; Zygosity=Heterozygous (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0504 (RKO)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=16762635; DOI=10.1053/j.gastro.2006.03.016
Eike Gallmeier, Eric S. Calhoun, Carlo Rago, Jonathan R. Brody, Steven C. Cunningham, Tomas Hucl, Myriam Gorospe, Manu Kohli, Christoph Lengauer, Scott E. Kern;
Targeted disruption of FANCC and FANCG in human cancer provides a preclinical model for specific therapeutic options.
Gastroenterology 130:2145-2154(2006)

Cross-references
Cell line collections (Providers) Horizon_Discovery; HD+R05-006
Cell line databases/resources cancercelllines; CVCL_HE20
Encyclopedic resources Wikidata; Q54950550
Entry history
Entry creation01-Dec-2016
Last entry update19-Dec-2024
Version number12