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Cellosaurus Panc 04.03 MAP2K4(-/-) (CVCL_HE14)

[Text version]
Cell line name Panc 04.03 MAP2K4(-/-)
Synonyms MAP2K4 (-/-) Panc 04.03; MKK4-/- cells
Accession CVCL_HE14
Resource Identification Initiative To cite this cell line use: Panc 04.03 MAP2K4(-/-) (RRID:CVCL_HE14)
Comments Population: Caucasian.
Knockout cell: Method=Homologous recombination; HGNC; 6844; MAP2K4.
Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
Sequence variations
  • Gene fusion; HGNC; 16935; ATG7 + HGNC; 9829; RAF1; Name(s)=ATG7-RAF1 (from parent cell line).
  • Mutation; HGNC; 583; APC; Simple; p.Thr1556fs*3 (c.4660_4661insA) (E1554fs); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gly245Ser (c.733G>A); ClinVar=VCV000012365; Zygosity=Homozygous (from parent cell line).
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1636 (Panc 04.03)
Sex of cell Male
Age at sampling 70Y
Category Cancer cell line
Publications

PubMed=16740690; DOI=10.1158/0008-5472.CAN-06-0555
Cunningham S.C., Gallmeier E., Hucl T., Dezentje D.A., Calhoun E.S., Falco G., Abdelmohsen K., Gorospe M., Kern S.E.
Targeted deletion of MKK4 in cancer cells: a detrimental phenotype manifests as decreased experimental metastasis and suggests a counterweight to the evolution of tumor-suppressor loss.
Cancer Res. 66:5560-5564(2006)

Cross-references
Cell line collections (Providers) Horizon_Discovery; HD+109-002
Cell line databases/resources cancercelllines; CVCL_HE14
Encyclopedic resources Wikidata; Q54937519
Entry history
Entry creation01-Dec-2016
Last entry update05-Oct-2023
Version number10