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Cellosaurus KMS-11 WHSC1(+/-) (CVCL_HE02)

[Text version]
Cell line name KMS-11 WHSC1(+/-)
Synonyms WHSC1 (+/-) KMS-11; KMS-11 MMSET T-KO; KMS-11/TKO; KMS11/TKO; TKO
Accession CVCL_HE02
Resource Identification Initiative To cite this cell line use: KMS-11 WHSC1(+/-) (RRID:CVCL_HE02)
Comments Population: Japanese.
Characteristics: Produces IgG kappa.
Characteristics: In KMS-11 one of the two WHSC1 alleles is translocated. This cell line is KO for the translocated allele.
Knockout cell: Method=Homologous recombination; HGNC; HGNC:12766; NSD2 (Note=1 of 2 alleles).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Cell type: Plasma cell; CL=CL_0000786.
Sequence variations
  • Gene fusion; HGNC; HGNC:5722; IGKJ4 + HGNC; HGNC:5739; IGKV1-37; Name(s)=IGKV1-37-IGKJ4 (from parent cell line).
  • Gene fusion; HGNC; HGNC:5723; IGKJ5 + HGNC; HGNC:5816; IGKV3-15; Name(s)=IGKV3-15-IGKJ5 (from parent cell line).
  • Mutation; HGNC; HGNC:3690; FGFR3; Simple; p.Tyr373Cys (c.1118A>G); ClinVar=VCV000016342; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:12033; TRAF3; Simple; p.Lys191Leufs*3; Zygosity=Homozygous (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2989 (KMS-11)
Sex of cell Female
Age at sampling 67Y
Category Cancer cell line
Publications

PubMed=17942756; DOI=10.1182/blood-2007-05-088674; PMCID=PMC2200833
Josh Lauring, Abde M. Abukhdeir, Hiroyuki Konishi, Joseph P. Garay, John P. Gustin, Qiu-Ju Wang, Robert John Arceci, William Matsui, Ben Ho Park;
The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity.
Blood 111:856-864(2008)

Cross-references
Cell line collections (Providers) Horizon_Discovery; HD+108-002
Cell line databases/resources cancercelllines; CVCL_HE02
Anatomy/cell type resources BTO; BTO_0005876
Encyclopedic resources Wikidata; Q54900163
Entry history
Entry creation01-Dec-2016
Last entry update14-Aug-2025
Version number17