| Cell line name |
HCT 116 XRCC6(+/-) |
|---|
| Synonyms |
XRCC6 (+/-) HCT116; Ku70+/- HCT116 |
|---|
| Accession |
CVCL_HE01 |
|---|
| Resource Identification Initiative |
To cite this cell line use: HCT 116 XRCC6(+/-) (RRID:CVCL_HE01) |
|---|
| Comments |
Population: Caucasian.
Knockout cell: Method=Homologous recombination; HGNC; 4055; XRCC6 (Note=1 of 2 alleles).
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
|---|
| Sequence variations |
- Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 1101; BRCA2; Simple; p.Ile2675Aspfs*6 (c.8021dupA) (c.8021_8022insA); ClinVar=VCV000267050; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 9277; PPM1D; Simple; p.Leu450Ter (c.1349delT) (p.Leu450fs) (c.1344delT); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
|
|---|
| Disease |
Colon carcinoma (NCIt: C4910) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_0291 (HCT 116) |
|---|
| Sex of cell |
Male |
|---|
| Age at sampling |
48Y |
|---|
| Category |
Cancer cell line |
|---|
| Publications | PubMed=18387344; DOI=10.1016/j.dnarep.2008.02.008
Fattah K.R., Ruis B.L., Hendrickson E.A.
Mutations to Ku reveal differences in human somatic cell lines.
DNA Repair 7:762-774(2008) PubMed=18562296; DOI=10.1073/pnas.0712060105
Fattah F.J., Lichter N.F., Fattah K.R., Oh S., Hendrickson E.A.
Ku70, an essential gene, modulates the frequency of rAAV-mediated gene targeting in human somatic cells.
Proc. Natl. Acad. Sci. U.S.A. 105:8703-8708(2008) PubMed=20195511; DOI=10.1371/journal.pgen.1000855
Fattah F.J., Lee E.H., Weisensel N., Wang Y.-B., Lichter N.F., Hendrickson E.A.
Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cells.
PLoS Genet. 6:E1000855-E1000855(2010) |
|---|
| Cross-references |
|---|
| Cell line collections (Providers) |
Horizon_Discovery; HD+R02-053
|
|---|
| Cell line databases/resources |
cancercelllines; CVCL_HE01
|
|---|
| Encyclopedic resources |
Wikidata; Q54881993
|
|---|
| Entry history |
|---|
| Entry creation | 01-Dec-2016 |
|---|
| Last entry update | 30-Jan-2024 |
|---|
| Version number | 13 |
|---|
