Cellosaurus cell line CHO 7PA2 (CVCL

Cellosaurus CHO 7PA2 (CVCL_HC66)

Cross-references
Cell line name	CHO 7PA2
Synonyms	CHO-7PA2; CHO7PA2; 7PA2
Accession	CVCL_HC66
Resource Identification Initiative	To cite this cell line use: CHO 7PA2 (RRID:CVCL_HC66)
Comments	Genetic integration: Method=Transfection; Gene=HGNC; HGNC:620; APP (Note=Isoform APP751; with p.Val717Phe). Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo. Derived from site: In situ; Ovary; UBERON=UBERON_0000992. Cell type: Epithelial cell of ovary; CL=CL_2000064.
Species of origin	Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy	Parent: CVCL_0214 (CHO-K1)
Sex of cell	Female
Age at sampling	Adult
Category	Spontaneously immortalized cell line
Publications	PubMed=7721886; DOI=10.1074/jbc.270.16.9564 Maria B. Podlisny, Beth L. Ostaszewski, Sharon L. Squazzo, Edward H. Koo, Russell E. Rydel, David B. Teplow, Dennis J. Selkoe; Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture. J. Biol. Chem. 270:9564-9570(1995) PubMed=23948918; DOI=10.3233/JAD-130728 Nina Krako, Maria Chiara Magnifico, Marzia Arese, Giovanni Meli, Elena Forte, Agnese Lecci, Annalisa Manca, Alessandro Giuffre, Daniela Mastronicola, Paolo Sarti, Antonino Cattaneo; Characterization of mitochondrial dysfunction in the 7PA2 cell model of Alzheimer's disease. J. Alzheimers Dis. 37:747-758(2013) PubMed=24840308; DOI=10.1021/bi5003053; PMCID=PMC4070750 Alfred T. Welzel, John Edward Maggio, Ganesh M. Shankar, Donald E. Walker, Beth L. Ostaszewski, Shao-Min Li, Igor Klyubin, Michael J. Rowan, Peter Seubert, Dominic Martin Walsh, Dennis J. Selkoe; Secreted amyloid beta-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity. Biochemistry 53:3908-3921(2014)
Encyclopedic resources	Wikidata; Q54812555
Entry history
Entry creation	01-Dec-2016
Last entry update	14-Aug-2025
Version number	12