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Cellosaurus MDA-IBC-3 (CVCL_HC47)

[Text version]
Cell line name MDA-IBC-3
Synonyms MDA-IBC3; MDAIBC3; MD Anderson-Inflammatory Breast Cancer-3
Accession CVCL_HC47
Resource Identification Initiative To cite this cell line use: MDA-IBC-3 (RRID:CVCL_HC47)
Comments Characteristics: ER-negative, PR-negative and ERBB2-positive.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Disease Breast inflammatory carcinoma (NCIt: C4001)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=20808935

Markers:
AmelogeninX
CSF1PO12,13
D5S81810,11
D7S8208,12
D13S31711,12
D16S5399,12
TH018
TPOX10,11
vWA18,19

Run an STR similarity search on this cell line
Publications

PubMed=20808935; DOI=10.1371/journal.pone.0012180; PMCID=PMC2922340
Ann H. Klopp, Lara Lacerda, Anshul Gupta, Bisrat G. Debeb, Travis Solley, Li Li, Erika Spaeth, Wei Xu, Xiao-Mei Zhang, Michael Thane Lewis, James M. Reuben ...Show all 19 authors... , Savitri Krishnamurthy, Mauro Ferrari, Rogerio Gaspar, Thomas A. Buchholz, Massimo Cristofanilli, Frank C. Marini, Michael Andreeff, Wendy A. Woodward; Show fewer authors
Mesenchymal stem cells promote mammosphere formation and decrease E-cadherin in normal and malignant breast cells.
PLoS ONE 5:e12180.1-e12180.9(2010)

DOI=10.4172/2161-0681.1000119
Fredika M. Robertson, Khoi Chu, Sandra V. Fernandez, Zhao-Mei Mu, Xue-Jun Zhang, Hui Liu, Kimberly M. Boley, R. Katherine Alpaugh, Zai-Ming Ye, Moishia C. Wright, Annie Z. Luo ...Show all 17 authors... , Ricardo Oraes, Hong Wu, Matthew Brent Zook, Sanford H. Barsky, Savitri Krishnamurthy, Massimo Cristofanilli; Show fewer authors
Genomic profiling of pre-clinical models of inflammatory breast cancer identifies a signature of epithelial plasticity and suppression of TGFbeta signaling.
J. Clin. Exp. Pathol. 2:119.1-119.11(2012)

PubMed=23784380; DOI=10.1007/s10549-013-2600-4; PMCID=PMC4273486
Sandra V. Fernandez, Fredika M. Robertson, Jian-Ming Pei, Lucy Doris Aburto-Chumpitaz, Zhao-Mei Mu, Khoi Chu, R. Katherine Alpaugh, Yong Huang, Yu Cao, Zai-Ming Ye, Kathy Q. Cai ...Show all 16 authors... , Kimberly M. Boley, Andres J.P. Klein-Szanto, Karthik Devarajan, Sankar Addya, Massimo Cristofanilli; Show fewer authors
Inflammatory breast cancer (IBC): clues for targeted therapies.
Breast Cancer Res. Treat. 140:23-33(2013)

PubMed=24162158; DOI=10.1007/s10549-013-2743-3; PMCID=PMC3832776
Aleix Prat, Olga Karginova, Joel S. Parker, Cheng Fan, Xia-Ping He, Lisa M. Bixby, J. Chuck Harrell, Erick Roman, Barbara Adamo, Melissa A. Troester, Charles M. Perou;
Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes.
Breast Cancer Res. Treat. 142:237-255(2013)

PubMed=35042871; DOI=10.1038/s41523-021-00379-6; PMCID=PMC8766434
Charlotte Rypens, Francois Bertucci, Pascal Finetti, Fredika M. Robertson, Sandra V. Fernandez, Naoto Tada Ueno, Wendy A. Woodward, Kenneth Van Golen, Peter Vermeulen, Luc Dirix, Patrice Viens ...Show all 15 authors... , Daniel Birnbaum, Gayathri R. Devi, Massimo Cristofanilli, Steven Van Laere; Show fewer authors
Comparative transcriptional analyses of preclinical models and patient samples reveal MYC and RELA driven expression patterns that define the molecular landscape of IBC.
NPJ Breast Cancer 8:12.1-12.12(2022)

Cross-references
Encyclopedic resources Wikidata; Q54904575
Gene expression databases ArrayExpress; E-MTAB-11134
GEO; GSM1008922
GEO; GSM1215265
GEO; GSM3145605
GEO; GSM3145722
Entry history
Entry creation01-Dec-2016
Last entry update14-Aug-2025
Version number10