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Cellosaurus ZP139 (CVCL_HB19)

[Text version]
Cell line name ZP139
Accession CVCL_HB19
Resource Identification Initiative To cite this cell line use: ZP139 (RRID:CVCL_HB19)
Comments Characteristics: Selected using the 9-(1'-pyrene)nonanol/ultraviolet (P9OH/UV) method. P9OH acts as a photosensitizer. Normal cells which can incorporate the fluorescent fatty alcohol into lipids are killed by UV, but mutants who incorporate P9OH poorly are less susceptible to photosensitized killing.
Genetic integration: Method=Transfection/transduction; Gene=RGD; 61814; Pex2.
Transformant: ChEBI; CHEBI_21759; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Sequence variations
  • Mutation; UniProtKB; Q920N5; Pex5; Simple; p.Gly530Glu (c.1589G>A) (G480E); Zygosity=Homozygous (PubMed=9418886).
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_HB34 (CHOTKa)
Sex of cell Female
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=9418886; DOI=10.1128/mcb.18.1.388; PMCID=PMC121509
Hidenori Otera, Kanji Okumoto, Keita Tateishi, Yuka Ikoma, Eiko Matsuda, Maki Nishimura, Toshiro Tsukamoto, Takashi Osumi, Kazumasa Ohashi, Osamu Higuchi, Yukio Fujiki;
Peroxisome targeting signal type 1 (PTS1) receptor is involved in import of both PTS1 and PTS2: studies with PEX5-defective CHO cell mutants.
Mol. Cell. Biol. 18:388-399(1998)

PubMed=11330042; DOI=10.1385/CBB:32:1-3:155
Yukio Fujiki, Kanji Okumoto, Hidenori Otera, Shigehiko Tamura;
Peroxisome biogenesis and molecular defects in peroxisome assembly disorders.
Cell Biochem. Biophys. 32:155-164(2000)

PubMed=17045664; DOI=10.1016/j.bbamcr.2006.09.012
Yukio Fujiki, Kanji Okumoto, Naohiko Kinoshita, Kamran Ghaedi;
Lessons from peroxisome-deficient Chinese hamster ovary (CHO) cell mutants.
Biochim. Biophys. Acta 1763:1374-1381(2006)

PubMed=23009329; DOI=10.1042/bj20120911
Ryuichi Natsuyama, Kanji Okumoto, Yukio Fujiki;
Pex5p stabilizes Pex14p: a study using a newly isolated pex5 CHO cell mutant, ZPEG101.
Biochem. J. 449:195-207(2013)

Cross-references
Encyclopedic resources Wikidata; Q54996025
Entry history
Entry creation01-Dec-2016
Last entry update19-Dec-2024
Version number14