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Cellosaurus H19-7 (CVCL_H781)

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Cell line name H19-7
Accession CVCL_H781
Resource Identification Initiative To cite this cell line use: H19-7 (RRID:CVCL_H781)
Comments Characteristics: Grows at the permissive temperature (34 Celsius). Differentiate to a neuronal phenotype at the nonpermissive temperature (39 Celsius) when induced by FGF2.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58).
Derived from site: In situ; Embryonic brain, hippocampus; UBERON=UBERON_0006238+UBERON_0002421.
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Breed/subspecies: Holtzman Sprague Dawley (HotHsd:SD); RS=RS_0002942.
Hierarchy Children:
CVCL_6493 (H19-7/IGF-IR)
Sex of cell Sex unspecified
Age at sampling 17FD
Category Transformed cell line
Publications

PubMed=1316607; DOI=10.1073/pnas.89.10.4373; PMCID=PMC49084
Eva M. Eves, Marcy S. Tucker, John D. Roback, Martha Downen, Marsha Rich Rosner, Bruce H. Wainer;
Immortal rat hippocampal cell lines exhibit neuronal and glial lineages and neurotrophin gene expression.
Proc. Natl. Acad. Sci. U.S.A. 89:4373-4377(1992)

PubMed=10786694
Andrea Morrione, Gaetano Romano, Magali Navarro, Krzysztof Reiss, Barbara Valentinis, Michael Dews, Eva M. Eves, Marsha Rich Rosner, Renato Baserga;
Insulin-like growth factor I receptor signaling in differentiation of neuronal H19-7 cells.
Cancer Res. 60:2263-2272(2000)

PubMed=22863662; DOI=10.1111/j.1582-4934.2012.01607.x; PMCID=PMC4118228
Asir Alwin Prem Anand, S. Gowri Sankar, Kokila V. Vani;
Immortalization of neuronal progenitors using SV40 large T antigen and differentiation towards dopaminergic neurons.
J. Cell. Mol. Med. 16:2592-2610(2012)

Cross-references
Cell line collections (Providers) ABM; T0359
Encyclopedic resources Wikidata; Q54871971
Experimental variables resources EFO; EFO_0022832
Entry history
Entry creation11-Feb-2013
Last entry update14-Aug-2025
Version number15