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Cellosaurus 6647 (CVCL_H722)

[Text version]
Cell line name 6647
Synonyms #6647
Accession CVCL_H722
Resource Identification Initiative To cite this cell line use: 6647 (RRID:CVCL_H722)
Comments Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
Disease Ewing sarcoma (NCIt: C4817)
Ewing sarcoma (ORDO: Orphanet_319)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): PubMed=25010205

Markers:
AmelogeninX
CSF1PO11,13
D2S133817,25
D3S135815,17
D5S81811,13
D7S8208,10
D8S117910,13
D13S3178
D16S53910,12
D18S5113,19
D19S43314,14.2
D21S1129,30
FGA22,24
TH019,9.3
TPOX8,9
vWA14,18

Run an STR similarity search on this cell line
Publications

PubMed=327080; DOI=10.1093/jnci/59.1.221
Jorgen Fogh, Jens M. Fogh, Thomas Orfeo;
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=3004699; DOI=10.1016/0165-4608(86)90001-4
Jacqueline Whang-Peng, Timothy J. Triche, Turid Knutsen, James S. Miser, Chien-Song Kao-Shan, Schickwann Tsai, Mark A. Israel;
Cytogenetic characterization of selected small round cell tumors of childhood.
Cancer Genet. Cytogenet. 21:185-208(1986)

PubMed=3390826
Catherine McKeon, Carol Jeanne Thiele, Robert A. Ross, Michael Kwan, Timothy J. Triche, James S. Miser, Mark A. Israel;
Indistinguishable patterns of protooncogene expression in two distinct but closely related tumors: Ewing's sarcoma and neuroepithelioma.
Cancer Res. 48:4307-4311(1988)

PubMed=8040301; DOI=10.1172/JCI117360; PMCID=PMC295111
Marco Giovannini, Jaclyn A. Biegel, Massimo Serra, Jian-Ying Wang, Ya-Lin H. Wei, Lynn M. Nycum, Beverly S. Emanuel, Glen A. Evans;
EWS-erg and EWS-Fli1 fusion transcripts in Ewing's sarcoma and primitive neuroectodermal tumors with variant translocations.
J. Clin. Invest. 94:489-496(1994)

PubMed=8617485; DOI=10.1016/S0046-8177(96)90115-X
Katia Scotlandi, Massimo Serra, Maria Cristina Manara, Stefania Benini, Manuela Sarti, Daniela Maurici, Pier-Luigi Lollini, Piero Picci, Francesco Bertoni, Nicola Baldini;
Immunostaining of the p30/32MIC2 antigen and molecular detection of EWS rearrangements for the diagnosis of Ewing's sarcoma and peripheral neuroectodermal tumor.
Hum. Pathol. 27:408-416(1996)

PubMed=11891184; DOI=10.1016/S0002-9440(10)64908-5; PMCID=PMC1867180
Maria Cristina Manara, Bernard Perbal, Stefania Benini, Rosaria Strammiello, Vanessa Cerisano, Stefania Perdichizzi, Massimo Serra, Annalisa Astolfi, Francesco Bertoni, Jennifer Alami, Herman Yeger ...Show all 13 authors... , Piero Picci, Katia Scotlandi; Show fewer authors
The expression of ccn3(nov) gene in musculoskeletal tumors.
Am. J. Pathol. 160:849-859(2002)

PubMed=18160777; DOI=10.1159/000109614
Suvi Savola, Filippo Nardi, Katia Scotlandi, Piero Picci, Sakari Knuutila;
Microdeletions in 9p21.3 induce false negative results in CDKN2A FISH analysis of Ewing sarcoma.
Cytogenet. Genome Res. 119:21-26(2007)

PubMed=22142829; DOI=10.1158/1078-0432.CCR-11-2056; PMCID=PMC3271129
Neerav Shukla, Nabahet Ameur, Ismail Yilmaz, Khedoudja Nafa, Chyau-Yueh Lau, Angela Marchetti, Laetitia Borsu, Frederic G. Barr, Marc Ladanyi;
Oncogene mutation profiling of pediatric solid tumors reveals significant subsets of embryonal rhabdomyosarcoma and neuroblastoma with mutated genes in growth signaling pathways.
Clin. Cancer Res. 18:748-757(2012)

PubMed=25010205; DOI=10.1371/journal.pgen.1004475; PMCID=PMC4091782
Andrew S. Brohl, David A. Solomon, Wendy Chang, Jian-Jun Wang, Young Song, Sivasish Sindiri, Rajesh Patidar, Laura Hurd, Li Chen, Jack F. Shern, Hong-Ling Liao ...Show all 26 authors... , Xin-Yu Wen, Julia Gerard, Jung-Sik Kim, Jose Antonio Lopez Guerrero, Isidro Machado, Daniel H. Wai, Piero Picci, Timothy J. Triche, Andrew E. Horvai, Markku Martti Miettinen, Jun S. Wei, Daniel Catchpoole, Antonio Llombart-Bosch, Todd A. Waldman, Javed Khan; Show fewer authors
The genomic landscape of the Ewing sarcoma family of tumors reveals recurrent STAG2 mutation.
PLoS Genet. 10:e1004475.1-e1004475.13(2014)

PubMed=26428435; DOI=10.1016/j.ejca.2015.08.020
Laurens G.L. Sand, Katia Scotlandi, Dagmar Berghuis, B. Ewa Snaar-Jagalska, Piero Picci, Thomas Schmidt, Karoly Szuhai, Pancras Cornelis Wilhelmus Hogendoorn;
CXCL14, CXCR7 expression and CXCR4 splice variant ratio associate with survival and metastases in Ewing sarcoma patients.
Eur. J. Cancer 51:2624-2633(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_H722
Encyclopedic resources Wikidata; Q53996682
Polymorphism and mutation databases Cosmic; 1078384
Cosmic; 1082508
Cosmic; 1718435
Cosmic; 2228212
Entry history
Entry creation11-Feb-2013
Last entry update10-Apr-2025
Version number27