| Cell line name |
A549/CPT |
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| Accession |
CVCL_H268 |
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| Resource Identification Initiative |
To cite this cell line use: A549/CPT (RRID:CVCL_H268) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_27656; Camptothecin (CPT).
Derived from site: In situ; Lung; UBERON=UBERON_0002048. |
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| Sequence variations |
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Lung adenocarcinoma (NCIt: C3512) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0023 (A-549) |
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| Sex of cell |
Male |
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| Age at sampling |
58Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=2170010
Yoshikazu Sugimoto, Satomi Tsukahara, Tomoko Oh-hara, Toshiyuki Isoe, Takashi Tsuruo;
Decreased expression of DNA topoisomerase I in camptothecin-resistant tumor cell lines as determined by a monoclonal antibody.
Cancer Res. 50:6925-6930(1990) PubMed=2174738
Yoshikazu Sugimoto, Satomi Tsukahara, Tomoko Oh-hara, Leroy Fong Liu, Takashi Tsuruo;
Elevated expression of DNA topoisomerase II in camptothecin-resistant human tumor cell lines.
Cancer Res. 50:7962-7965(1990) PubMed=14973057; DOI=10.1158/0008-5472.CAN-3263-2
Kohichiroh Yasui, Saori Mihara, Chen Zhao, Hiroyuki Okamoto, Fumiko Saito-Ohara, Akihiro Tomida, Tadao Funato, Akira Yokomizo, Seiji Naito, Issei Imoto, Takashi Tsuruo, Johji Inazawa;
Alteration in copy numbers of genes as a mechanism for acquired drug resistance.
Cancer Res. 64:1403-1410(2004) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_H268
CGH-DB; 9107-4
|
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| Encyclopedic resources |
Wikidata; Q54607045
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| Entry history |
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| Entry creation | 11-Feb-2013 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 16 |
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