Cellosaurus logo
expasy logo

Cellosaurus A549/CPT (CVCL_H268)

[Text version]
Cell line name A549/CPT
Accession CVCL_H268
Resource Identification Initiative To cite this cell line use: A549/CPT (RRID:CVCL_H268)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:27656; Camptothecin (CPT).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=2170010
Sugimoto Y., Tsukahara S., Oh-hara T., Isoe T., Tsuruo T.
Decreased expression of DNA topoisomerase I in camptothecin-resistant tumor cell lines as determined by a monoclonal antibody.
Cancer Res. 50:6925-6930(1990)

PubMed=2174738
Sugimoto Y., Tsukahara S., Oh-hara T., Liu L.F., Tsuruo T.
Elevated expression of DNA topoisomerase II in camptothecin-resistant human tumor cell lines.
Cancer Res. 50:7962-7965(1990)

PubMed=14973057; DOI=10.1158/0008-5472.CAN-3263-2
Yasui K., Mihara S., Zhao C., Okamoto H., Saito-Ohara F., Tomida A., Funato T., Yokomizo A., Naito S., Imoto I., Tsuruo T., Inazawa J.
Alteration in copy numbers of genes as a mechanism for acquired drug resistance.
Cancer Res. 64:1403-1410(2004)

Cross-references
Cell line databases/resources cancercelllines; CVCL_H268
CGH-DB; 9107-4
Encyclopedic resources Wikidata; Q54607045
Entry history
Entry creation11-Feb-2013
Last entry update05-Oct-2023
Version number15