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Cellosaurus ST-4 (CVCL_H267)

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Cell line name ST-4
Accession CVCL_H267
Resource Identification Initiative To cite this cell line use: ST-4 (RRID:CVCL_H267)
Comments Problematic cell line: Contaminated. Shown to be a PF-382 derivative. Originally thought to originate from the axillary lymph node biopsy of a 12 year old boy with a T-cell malignant lymphoma.
Population: Caucasian.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1574Pro (c.4721T>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2493fs*67 (c.7476_7477ins11); Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1641 (PF-382)
Sex of cell Female
Age at sampling 6Y
Category Cancer cell line
Web pages Info; DSMZ; -; https://www.dsmz.de/fileadmin/Bereiche/HumanandAnimalCellLines/False_LL_Cell_Lines.pdf
Publications

PubMed=3257718
Roberto Arione, Cristina Jemma, Marco Forni, Cristiana Marchese, Gabriella Benetton, Cristina Giubellino, Andrea Modesti, Maria Giovanna Martinotti, Luca Cordero di Montezemolo, Tiziana Musso, Guido Forni;
A new childhood T-cell lymphoma established in nude mice and in vitro.
Cancer Res. 48:1312-1318(1988)

PubMed=8558920
Wilhelm Gerhard Dirks, Margarete Zaborski, Kathrin Jager, Cecile Challier, Mami Shiota, Hilmar Quentmeier, Hans Gunther Drexler;
The (2;5)(p23;q35) translocation in cell lines derived from malignant lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.
Leukemia 10:142-149(1996)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

Cross-references
Encyclopedic resources Wikidata; Q54955733
Polymorphism and mutation databases Cosmic; 1086321
Entry history
Entry creation11-Feb-2013
Last entry update10-Apr-2025
Version number19