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Cellosaurus MCF-7/C4-12 (CVCL_GX99)

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Cell line name MCF-7/C4-12
Synonyms MCF-7 C4-12; MCF7 C4-12; MCF-7:C4-12; MCF-7C4-12; C4-12
Accession CVCL_GX99
Resource Identification Initiative To cite this cell line use: MCF-7/C4-12 (RRID:CVCL_GX99)
Comments Population: Caucasian.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=11479214
Steffi Oesterreich, Ping Zhang, Rebecca L. Guler, Xiu-Hua Sun, Edward M. Curran, Wade V. Welshons, Charles Kent Osborne, Adrian V. Lee;
Re-expression of estrogen receptor alpha in estrogen receptor alpha-negative MCF-7 cells restores both estrogen and insulin-like growth factor-mediated signaling and growth.
Cancer Res. 61:5771-5777(2001)

Cross-references
Cell line databases/resources cancercelllines; CVCL_GX99
TOKU-E; 4086
Encyclopedic resources Wikidata; Q54904358
Experimental variables resources EFO; EFO_0022701
Entry history
Entry creation26-Sep-2016
Last entry update19-Dec-2024
Version number14