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Cellosaurus BR (CVCL_GT42)

[Text version]
Cell line name BR
Synonyms BRMCT
Accession CVCL_GT42
Resource Identification Initiative To cite this cell line use: BR (RRID:CVCL_GT42)
Comments Doubling time: 36 hours (PubMed=27257868).
Omics: Genomics; Whole exome sequencing.
Sequence variations
  • Mutation; VGNC; VGNC:42422; KIT; Simple; p.Leu575Pro (c.1724T>C); Zygosity=Heterozygous (PubMed=31175136).
  • Mutation; VGNC; VGNC:46054; SETD2; Simple; p.Arg526fs (c.1576delA); Zygosity=Homozygous (PubMed=31175136).
  • Mutation; VGNC; VGNC:47719; TP53; Simple; p.Ala193Asp (c.578C>A); Zygosity=Heterozygous (PubMed=31175136).
  • Mutation; VGNC; VGNC:47719; TP53; Simple; p.Arg263Cys (c.787C>T); Zygosity=Heterozygous (PubMed=31175136).
Disease Canine mastocytoma (NCIt: C129077)
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=31175136

Markers:
Dog FHC2010227,235
Dog FHC2054180
Dog FHC2079279
Dog PEZ1111,119
Dog PEZ12270,274
Dog PEZ20176,180
Dog PEZ3121,134
Dog PEZ5103,109
Dog PEZ6180,184
Dog PEZ8228,242

Run an STR similarity search on this cell line
Publications

PubMed=1634619; DOI=10.1172/JCI115853; PMCID=PMC443060
Daniel W. Pennington, Alfredo R. Lopez, Paul S. Thomas, Caroline Peck, Warren M. Gold;
Dog mastocytoma cells produce transforming growth factor beta 1.
J. Clin. Invest. 90:35-41(1992)

PubMed=9646437; DOI=10.1016/S0165-2427(97)00166-9
Gloria Garcia, Pilar Brazis, Natalia Majo, Lluis Ferrer, Fernando de Mora, Anna Puigdemont;
Comparative morphofunctional study of dispersed mature canine cutaneous mast cells and BR cells, a poorly differentiated mast cell line from a dog subcutaneous mastocytoma.
Vet. Immunol. Immunopathol. 62:323-337(1998)

PubMed=10210327; DOI=10.1016/S0301-472X(98)00075-7
Cheryl A. London, Stephen Joseph Galli, Toshifumi Yuuki, Zhi-Qing Hu, Stuart C. Helfand, Edwin N. Geissler;
Spontaneous canine mast cell tumors express tandem duplications in the proto-oncogene c-kit.
Exp. Hematol. 27:689-697(1999)

PubMed=27257868; DOI=10.1371/journal.pone.0156689; PMCID=PMC4892608
Junko Maeda, Coral Eva Froning, Colleen A. Brents, Barbara J. Rose, Douglas H. Thamm, Takamitsu A. Kato;
Intrinsic radiosensitivity and cellular characterization of 27 canine cancer cell lines.
PLoS ONE 11:e0156689.1-e0156689.18(2016)

PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346; PMCID=PMC6679748
Sunetra Das, Rupa Idate, Kathryn E. Cronise, Daniel L. Gustafson, Dawn L. Duval;
Identifying candidate druggable targets in canine cancer cell lines using whole-exome sequencing.
Mol. Cancer Ther. 18:1460-1471(2019)

Cross-references
Encyclopedic resources Wikidata; Q54798117
Entry history
Entry creation26-Sep-2016
Last entry update10-Apr-2025
Version number10