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Cellosaurus B16-F10-Nex2 (CVCL_F942)

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Cell line name B16-F10-Nex2
Synonyms B16F10-Nex2; B16F10-NEX2; B16F10Nex2; B16Nex2; Nex2
Accession CVCL_F942
Resource Identification Initiative To cite this cell line use: B16-F10-Nex2 (RRID:CVCL_F942)
Comments Characteristics: Melanotic. Shows low immunogenicity and moderate virulence. Forms subcutaneous tumours which are lethal, but do not metastasize to the lung unless injected intravenously (PubMed=15457088).
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Disease Mouse melanoma (NCIt: C21790)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6.
Hierarchy Parent: CVCL_0159 (B16-F10)
Children:
CVCL_C3Q1 (B16-F10-Nex4)CVCL_C3PY (Nex2B)CVCL_C3PZ (Nex2D)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=12470474; DOI=10.1089/153685902761022661
Andrey S. Dobroff, Elaine G. Rodrigues, Jane Zveiter de Moraes, Luiz Rodolpho Travassos;
Protective, anti-tumor monoclonal antibody recognizes a conformational epitope similar to melibiose at the surface of invasive murine melanoma cells.
Hybrid. Hybridomics 21:321-331(2002)

PubMed=15457088; DOI=10.1097/00008390-200410000-00002
Zenilda F.O. Freitas, Elaine G. Rodrigues, Vitor Oliveira, Adriana Karaoglanovic Carmona, Luiz Rodolpho Travassos;
Melanoma heterogeneity: differential, invasive, metastatic properties and profiles of cathepsin B, D and L activities in subclones of the B16F10-NEX2 cell line.
Melanoma Res. 14:333-344(2004)

PubMed=20689762; DOI=10.1593/tlo.09316; PMCID=PMC2915412
Andrey S. Dobroff, Elaine G. Rodrigues, Maria A. Juliano, Dayson Friaca Moreira, Ernesto Satoshi Nakayasu, Igor C. Almeida, Renato A. Mortara, Jacqueline Fatima Jacysyn, Gustavo P. Amarante-Mendes, Walter Magliani, Stefania Conti ...Show all 13 authors... , Luciano Polonelli, Luiz Rodolpho Travassos; Show fewer authors
Differential antitumor effects of IgG and IgM monoclonal antibodies and their synthetic complementarity-determining regions directed to new targets of B16F10-Nex2 melanoma cells.
Transl. Oncol. 3:204-217(2010)

Cross-references
Cell line collections (Providers) BCRJ; 0342
Anatomy/cell type resources BTO; BTO_0003424
Chemistry resources ChEMBL-Cells; CHEMBL4482994
ChEMBL-Targets; CHEMBL4483228
PubChem_Cell_line; CVCL_F942
Encyclopedic resources Wikidata; Q54752446
Entry history
Entry creation11-Feb-2013
Last entry update14-Aug-2025
Version number12