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Cellosaurus KK (CVCL_F844)

[Text version]
Cell line name KK
Accession CVCL_F844
Resource Identification Initiative To cite this cell line use: KK (RRID:CVCL_F844)
Comments Part of: MD Anderson Cell Lines Project.
Population: Japanese.
Doubling time: ~4 days (Note=At 70th passage) (PubMed=8148309); 31 hours (PubMed=8375936).
Omics: Genomics; Whole genome sequencing.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Disease Ovarian clear cell adenocarcinoma (NCIt: C40078)
Clear cell adenocarcinoma of the ovary (ORDO: Orphanet_398971)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 46Y
Category Cancer cell line
STR profile Source(s): PubMed=30485824

Markers:
AmelogeninX
CSF1PO11,12
D5S81810,11
D7S82010,11
D13S3178,11
D16S53911,12
D21S1130,31.2
TH017,9
TPOX8,9
vWA14,17

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=8148309
Hidenori Sasa, Kenji Ishii, Junko Hirata, Yoshihiro Kikuchi, Ichiro Nagata, Toshiaki Kawai, Akira Senoo, Michio Sugita, Tadashi Sugishita, Yoshio Tenjin;
Establishment and characterization of a CA125-producing human ovarian clear cell carcinoma cell line.
Hum. Cell 6:279-286(1993)

PubMed=8375936; DOI=10.1002/ijc.2910550332
Junko Hirata, Yoshihiro Kikuchi, Tsunekazu Kita, Eiji Imaizumi, Takehiko Tode, Kenji Ishii, Kazuya Kudoh, Ichiro Nagata;
Modulation of sensitivity of human ovarian cancer cells to cis-diamminedichloroplatinum(II) by 12-O-tetradecanoylphorbol-13-acetate and D,L-buthionine-S,R-sulphoximine.
Int. J. Cancer 55:521-527(1993)

PubMed=7844449
Kenji Ishii, Tsunekazu Kita, Kazuya Kudo, Atsushi Hisano, Junko Hirata, Eiji Imaizumi, Takehiko Tode, Yoshihiro Kikuchi, Ichiro Nagata;
Circumvention of cisplatin resistant ovarian cancer cells by antiestrogens.
Nihon Sanka Fujinka Gakkai Zasshi 47:19-26(1995)

PubMed=15677628; DOI=10.1093/carcin/bgi032
Kylie Louise Gorringe, Suet-Feung Chin, Paul D.P. Pharoah, Joanne M. Staines, Carla Oliveira, Paul A.W. Edwards, Carlos Caldas;
Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer.
Carcinogenesis 26:923-930(2005)

PubMed=17671176; DOI=10.1158/0008-5472.CAN-06-4567
Ryoko Kikuchi, Hitoshi Tsuda, Yae Kanai, Takahiro Kasamatsu, Kazuo Sengoku, Setsuo Hirohashi, Johji Inazawa, Issei Imoto;
Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer.
Cancer Res. 67:7095-7105(2007)

PubMed=20081105; DOI=10.1210/me.2009-0295; PMCID=PMC2817607
Ankur K. Nagaraja, Chad Jeremy Creighton, Zhi-Feng Yu, Hui-Feng Zhu, Preethi H. Gunaratne, Jeffrey G. Reid, Emuejevoke Olokpa, Hiroaki Itamochi, Naoto Tada Ueno, Shannon M. Hawkins, Matthew Linley Anderson, Martin Matthew Matzuk;
A link between mir-100 and FRAP1/mTOR in clear cell ovarian cancer.
Mol. Endocrinol. 24:447-463(2010)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30485824; DOI=10.1016/j.celrep.2018.10.096; PMCID=PMC6481945
Eniko Papp, Dorothy Hallberg, Gottfried E. Konecny, Daniel C. Bruhm, Vilmos Adleff, Michael Noe, Ioannis Kagiampakis, Doreen Palsgrove, Dylan Conklin, Yasuto Kinose, James R. White ...Show all 18 authors... , Michael F. Press, Ronny I. Drapkin, Hariharan Easwaran, Stephen Bruce Baylin, Dennis Joseph Slamon, Victor E. Velculescu, Robert B. Scharpf; Show fewer authors
Integrated genomic, epigenomic, and expression analyses of ovarian cancer cell lines.
Cell Rep. 25:2617-2633(2018)

Cross-references
Cell line databases/resources CGH-DB; 328-2
Encyclopedic resources Wikidata; Q54899964
Gene expression databases GEO; GSM416676
GEO; GSM659379
Polymorphism and mutation databases Cosmic; 931361
Cosmic; 1223313
Cosmic; 1328072
Cosmic; 1434897
Cosmic; 2074242
Cosmic; 2482702
Entry history
Entry creation11-Feb-2013
Last entry update10-Apr-2025
Version number17