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Cellosaurus STF1-169 (CVCL_F744)

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Cell line name STF1-169
Synonyms STF1.169
Accession CVCL_F744
Resource Identification Initiative To cite this cell line use: STF1-169 (RRID:CVCL_F744)
Comments Population: Moroccan.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
  • Mutation; HGNC; HGNC:44; TAP2; Simple; p.Arg273Ter (c.817C>T) (R253*); ClinVar=VCV000013727; Zygosity=Homozygous (from parent cell line).
Disease Bare lymphocyte syndrome type 1 (NCIt: C171267)
Immunodeficiency by defective expression of MHC class I (ORDO: Orphanet_34592)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_A5NE (STF-1)
Sex of cell Male
Age at sampling 6Y
Category Transformed cell line
Publications

PubMed=17977821; DOI=10.1074/jbc.M708139200
Ozlem Demirel, Zoe Waibler, Ulrich Kalinke, Frank Grunebach, Silke Appel, Peter Brossart, Andrej Hasilik, Robert Tampe, Rupert Abele;
Identification of a lysosomal peptide transport system induced during dendritic cell development.
J. Biol. Chem. 282:37836-37843(2007)

PubMed=18802093; DOI=10.4049/jimmunol.181.7.4894
Marieke C. Verweij, Danijela Koppers-Lalic, Sandra Loch, Florian Klauschies, Henri de la Salle, Edwin Quinten, Paul Joseph Lehner, Arend Mulder, Michael R. Knittler, Robert Tampe, Joachim Koch ...Show all 13 authors... , Maaike Elisabeth Ressing, Emmanuel J.H.J. Wiertz; Show fewer authors
The varicellovirus UL49.5 protein blocks the transporter associated with antigen processing (TAP) by inhibiting essential conformational transitions in the 6+6 transmembrane TAP core complex.
J. Immunol. 181:4894-4907(2008)

Cross-references
Anatomy/cell type resources BTO; BTO_0003755
Encyclopedic resources Wikidata; Q54970575
Entry history
Entry creation11-Feb-2013
Last entry update19-Dec-2024
Version number12