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Cellosaurus FEOXCS ESC clone 2 (CVCL_F6KE)

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Cell line name FEOXCS ESC clone 2
Synonyms FEOXCS; clone 2
Accession CVCL_F6KE
Resource Identification Initiative To cite this cell line use: FEOXCS ESC clone 2 (RRID:CVCL_F6KE)
Comments Characteristics: Expresses the FEOX sensor, composed of mTagBFP2 fused to a FBXL5 hemerythrin-like iron/oxygen-sensing domain, together with mCherry as control reporter.
Genetic integration: Method=PiggyBac transposition; Gene=FPbase; ZERB6; mCherry (Note=Red fluorescent protein derived from drFP583 (dsRed)).
Genetic integration: Method=PiggyBac transposition; Gene=FPbase; ZO7NN; mTagBFP2 (Note=Blue fluorescent protein derived from eqFP578).
Genetic integration: Method=PiggyBac transposition; Gene=HGNC; HGNC:13602; FBXL5 (Note=AA 1-161 = hemerythrin-like).
Derived from site: In situ; Blastocyst; UBERON=UBERON_0000358.
Cell type: Embryonic stem cell; CL=CL_0002322.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: C57BL/6J x 129S4/SvJae.
Hierarchy Parent: CVCL_C865 (v6.5)
Sex of cell Male
Age at sampling Blastocyst stage
Category Embryonic stem cell
Publications

PubMed=41120533; DOI=10.1038/s41598-025-20428-5; PMCID=PMC12541023
Carolyn Sangokoya;
The genetically encoded biosensor FEOX is a molecular gauge for cellular iron environment dynamics at single cell resolution.
Sci. Rep. 15:36596-36596(2025)

Entry history
Entry creation25-Jun-2026
Last entry update25-Jun-2026
Version number1