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Cellosaurus SW598 (CVCL_F649)

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Cell line name SW598
Synonyms SW-598; SW 598
Accession CVCL_F649
Resource Identification Initiative To cite this cell line use: SW598 (RRID:CVCL_F649)
Comments Problematic cell line: Contaminated. Shown to be a SW480 (or SW620) derivative (PubMed=288927; PubMed=20143388). Originally thought to originate from a 63 year old female patient with a meningioma.
From: Scott and White Clinic; Temple; USA.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00090.
Population: Caucasian.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Gln1338Ter (c.4012C>T); ClinVar=VCV000000801; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro309Ser (c.925C>T); ClinVar=VCV000458575; Zygosity=Heterozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0546 (SW480)
Sex of cell Male
Age at sampling 51Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2176

Markers:
AmelogeninX
CSF1PO13,14
D5S81813
D7S8208
D13S31712
D16S53913
TH018
TPOX11
vWA16

Run an STR similarity search on this cell line
Web pages Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/sw-598-sw-598-sw598-atcc-crl-2176
Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=833871; DOI=10.1093/jnci/58.2.209
Jorgen Fogh, William C. Wright, James D. Loveless;
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=288927; DOI=10.1093/jnci/63.3.635
Albert Leibovitz, William C. Wright, Sen Pathak, Michael Joseph Siciliano, Walter P. Daniels, Helle Fogh, Jorgen Fogh;
Detection and analysis of a glucose 6-phosphate dehydrogenase phenotype B cell line contamination.
J. Natl. Cancer Inst. 63:635-645(1979)

PubMed=20143388; DOI=10.1002/ijc.25242
Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney;
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Cell line collections (Providers) ATCC; CRL-2176 - Discontinued
Cell line databases/resources cancercelllines; CVCL_F649
Biological sample resources BioSample; SAMN03151931
Encyclopedic resources Wikidata; Q54971181
Entry history
Entry creation11-Feb-2013
Last entry update10-Apr-2025
Version number30