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Cellosaurus EDITGENE SPDEF Knockout HEC-1-B Cell Line (CVCL_F5C1)

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Cell line name EDITGENE SPDEF Knockout HEC-1-B Cell Line
Synonyms SPDEF Knockout HEC-1-B Cell Line
Accession CVCL_F5C1
Resource Identification Initiative To cite this cell line use: EDITGENE SPDEF Knockout HEC-1-B Cell Line (RRID:CVCL_F5C1)
Comments Population: Japanese.
Characteristics: Growth mode Adherent.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:17257; SPDEF.
Genetic integration: Method=CRISPR/Cas9; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Endometrium; UBERON=UBERON_0001295.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7329; MSH6; Simple; c.4001+1G>T; ClinVar=VCV001736936; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:9122; PMS2; Simple; p.Arg802Ter (c.2404C>T); ClinVar=VCV000009237; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; None_reported; -; Zygosity=- (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Type II endometrial adenocarcinoma (NCIt: C39749)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0294 (HEC-1-B)
Sex of cell Female
Age at sampling 71Y
Category Cancer cell line
STR profile Source(s): EDITGENE=EDC07683

Markers:
CSF1PO10,12
D5S81811,13
D7S8209,11
D13S31711,16
D16S53911,12
TH016,7
TPOX8,11
vWA18

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Cross-references
Cell line collections (Providers) EDITGENE; EDC07683
Entry history
Entry creation25-Jun-2026
Last entry update25-Jun-2026
Version number1