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Cellosaurus HyCyte MDA-MB-453 stable cell line for hCPB1 overexpression (CVCL_F4UA)

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Cell line name HyCyte MDA-MB-453 stable cell line for hCPB1 overexpression
Synonyms MDA-MB-453 stable cell line for hCPB1 overexpression
Accession CVCL_F4UA
Resource Identification Initiative To cite this cell line use: HyCyte MDA-MB-453 stable cell line for hCPB1 overexpression (RRID:CVCL_F4UA)
Comments Population: Caucasian.
Characteristics: Transfected with pPB[Exp]-EF1A>EGFP-CAG>hCPB1[NM_001871.3]-PGK>Puro.
Doubling time: 48-72 hours (Hysigen=CGSC-M35141).
Genetic integration: Method=PiggyBac transposition; Gene=FPbase; R9NL8; EGFP.
Genetic integration: Method=PiggyBac transposition; Gene=HGNC; HGNC:2299; CPB1.
Genetic integration: Method=PiggyBac transposition; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: Metastatic; Pericardial effusion; UBERON=UBERON_0002409.
Sequence variations
  • Mutation; HGNC; HGNC:644; AR; Simple; p.Gln868His (c.2604G>T); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:1748; CDH1; Simple; p.Trp638Ter (c.1913G>A); ClinVar=VCV000599651; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Glu307Lys (c.919G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Unexplicit; Ex10-11del; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0418 (MDA-MB-453)
Sex of cell Female
Age at sampling 48Y
Category Cancer cell line
Cross-references
Cell line collections (Providers) Hysigen; CGSC-M35141
Entry history
Entry creation25-Jun-2026
Last entry update25-Jun-2026
Version number1