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Cellosaurus HyCyte NCI-H1975 stable cell line for hPTK7 overexpression (CVCL_F4U4)

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Cell line name HyCyte NCI-H1975 stable cell line for hPTK7 overexpression
Synonyms NCI-H1975 stable cell line for hPTK7 overexpression
Accession CVCL_F4U4
Resource Identification Initiative To cite this cell line use: HyCyte NCI-H1975 stable cell line for hPTK7 overexpression (RRID:CVCL_F4U4)
Comments Population: Caucasian.
Characteristics: Transfected with pPB[Exp]-EF1A>EGFP-CAG>hPTK7[NM_002821.5]-PGK>Puro.
Doubling time: 36-48 hours (Hysigen=CGSC-M35011).
Genetic integration: Method=PiggyBac transposition; Gene=FPbase; R9NL8; EGFP.
Genetic integration: Method=PiggyBac transposition; Gene=HGNC; HGNC:9618; PTK7.
Genetic integration: Method=PiggyBac transposition; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Gly118Asp (c.353G>A); ClinVar=VCV000156446; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1511 (NCI-H1975)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Cross-references
Cell line collections (Providers) Hysigen; CGSC-M35011
Entry history
Entry creation25-Jun-2026
Last entry update25-Jun-2026
Version number1