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Cellosaurus HyCyte HCC1937 stable cell line for hBRCA1 overexpression (CVCL_F4NA)

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Cell line name HyCyte HCC1937 stable cell line for hBRCA1 overexpression
Synonyms HCC1937 stable cell line for hBRCA1 overexpression
Accession CVCL_F4NA
Resource Identification Initiative To cite this cell line use: HyCyte HCC1937 stable cell line for hBRCA1 overexpression (RRID:CVCL_F4NA)
Comments Population: Caucasian.
Characteristics: Transfected with pPB[Exp]-EF1A>EGFP-CAG>hBRCA1[NM_007300.4]-PGK>Puro.
Doubling time: 36-48 hours (Hysigen=CGSC-M33391).
Genetic integration: Method=PiggyBac transposition; Gene=FPbase; R9NL8; EGFP.
Genetic integration: Method=PiggyBac transposition; Gene=HGNC; HGNC:1100; BRCA1.
Genetic integration: Method=PiggyBac transposition; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Sequence variations
  • Gene deletion; HGNC; HGNC:9588; PTEN; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1100; BRCA1; Simple; p.Gln1756Profs*74 (c.5266dupC) (5382insC); ClinVar=VCV000017677; Zygosity=Homozygous; Note=The lymphoblastoid cell line HCC1937 BL (Cellosaurus=CVCL_3281) is heterozygous for the same mutation (from parent cell line).
  • Mutation; HGNC; HGNC:9884; RB1; Simple; p.Thr738_Arg775del38 (c.2212_2325del114); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11876; TMPRSS2; Simple; p.Gly8Val (c.23G>T) (c.-57+99G>T); ClinVar=VCV001273671; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11876; TMPRSS2; Simple; p.Val197Met (c.589G>A) (p.Val160Met, c.478G>A); ClinVar=VCV001257425; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Homozygous (from parent cell line).
Disease Breast ductal carcinoma (NCIt: C4017)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0290 (HCC1937)
Sex of cell Female
Age at sampling 24Y
Category Cancer cell line
Cross-references
Cell line collections (Providers) Hysigen; CGSC-M33391
Entry history
Entry creation25-Jun-2026
Last entry update25-Jun-2026
Version number1