Cellosaurus cell line HyCyte A-549 hRB1CC1_p.R474H_c.1421G>A_c.1422C>T cell line (CVCL

Cross-references
Cell line name	HyCyte A-549 hRB1CC1_p.R474H_c.1421G>A_c.1422C>T cell line
Synonyms	hRB1CC1_p.R474H_c.1421G>A_c.1422C>T cell line
Accession	CVCL_F4JU
Resource Identification Initiative	To cite this cell line use: HyCyte A-549 hRB1CC1_p.R474H_c.1421G>A_c.1422C>T cell line (RRID:CVCL_F4JU)
Comments	Population: Caucasian. Doubling time: 36-48 hours (Hysigen=CGMU-M2206). Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations	Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:15574; RB1CC1; Simple_edited; p.R474H (NM_001083617.1:c.1421_1422GC>AT); Zygosity=Homozygous (Hysigen=CGMU-M2206). Mutation; HGNC; HGNC:15574; RB1CC1; Simple_edited; p.L475L (NM_001083617.1:c.1425C>G); Zygosity=Homozygous; Note=Synonymous mutation (Hysigen=CGMU-M2206). Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (from parent cell line).
Disease	Lung adenocarcinoma (NCIt: C3512)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0023 (A-549)
Sex of cell	Male
Age at sampling	58Y
Category	Cancer cell line
Cell line collections (Providers)	Hysigen; CGMU-M2206
Entry history
Entry creation	25-Jun-2026
Last entry update	25-Jun-2026
Version number	1