Cellosaurus cell line HyCyte RKO KO-hRNF138 (CVCL

Cellosaurus HyCyte RKO KO-hRNF138 (CVCL_F4JK)

Cross-references
Cell line name	HyCyte RKO KO-hRNF138
Synonyms	hRNF138 knockout RKO cell line
Accession	CVCL_F4JK
Resource Identification Initiative	To cite this cell line use: HyCyte RKO KO-hRNF138 (RRID:CVCL_F4JK)
Comments	Doubling time: 24-36 hours (Hysigen=CGKO-M3558). Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:17765; RNF138. Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations	Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Leu452Pro (c.1355T>C); ClinVar=VCV000930524; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (from parent cell line).
Disease	Colon carcinoma (NCIt: C4910)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0504 (RKO)
Sex of cell	Sex unspecified
Age at sampling	Age unspecified
Category	Cancer cell line
Cell line collections (Providers)	Hysigen; CGKO-M3558
Entry history
Entry creation	25-Jun-2026
Last entry update	25-Jun-2026
Version number	1