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Cellosaurus HyCyte U2OS KO-hPTPN11 (CVCL_F4IR)

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Cell line name HyCyte U2OS KO-hPTPN11
Synonyms hPTPN11 knockout U2OS cell line
Accession CVCL_F4IR
Resource Identification Initiative To cite this cell line use: HyCyte U2OS KO-hPTPN11 (RRID:CVCL_F4IR)
Comments Population: Caucasian.
Doubling time: 18-24 hours (Hysigen=CGKO-M2156).
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:9644; PTPN11.
Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Sequence variations
  • Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0042 (U2OS)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
Cross-references
Cell line collections (Providers) Hysigen; CGKO-M2156
Entry history
Entry creation25-Jun-2026
Last entry update25-Jun-2026
Version number1