Cellosaurus cell line 876135-273-R-J3-PDC (CVCL

Cellosaurus 876135-273-R-J3-PDC (CVCL_F4DI)

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Cell line name

876135-273-R-J3-PDC

Accession

CVCL_F4DI

Resource Identification Initiative

To cite this cell line use: 876135-273-R-J3-PDC (RRID:CVCL_F4DI)

Comments

Part of: NCI Patient-Derived Model Repository.
Population: Caucasian; Utah residents with ancestry from Northern and Western Europe.
Characteristics: tumorigenic in NOD/SCID/IL2RgammaNULL (NSG) mice.
Characteristics: Established from a patient-derived xenograft (PDX) in NOD/SCID/IL2RgammaNULL (NSG) mice.
Doubling time: 52 hours (NCI-PDMR=8847).
Microsatellite instability: Stable (MSS) (NCI-PDMR=8847).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Derived from site: Metastatic; Left axillary lymph node; UBERON=UBERON_0001097.

Sequence variations

Mutation; HGNC; HGNC:20473; BRIP1; Simple; c.3749_*12del; Zygosity=Heterozygous; Note=Likely Oncogenic, variant allele frequency: 0.2632 (NCI-PDMR=8847).
Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.R80* (c.238C>T); Zygosity=Homozygous; Note=Likely Oncogenic, variant allele frequency: 1 (NCI-PDMR=8847).
Mutation; HGNC; HGNC:7067; CIITA; Simple; p.Q555* (c.1663C>T); Zygosity=Heterozygous; Note=Likely Oncogenic, variant allele frequency: 0.4685 (NCI-PDMR=8847).
Mutation; HGNC; HGNC:7652; NBN; Simple; p.K219Nfs*16 (c.657_661del); Zygosity=Unspecified; Note=Likely Oncogenic, variant allele frequency: 0.1429 (NCI-PDMR=8847).
Mutation; HGNC; HGNC:7765; NF1; Simple; p.R1362* (c.4083_4084delinsCT); Zygosity=Homozygous; Note=Likely Oncogenic, variant allele frequency: 1 (NCI-PDMR=8847).
Mutation; HGNC; HGNC:7989; NRAS; Simple; p.G13D (c.38G>A); Zygosity=Heterozygous; Note=Oncogenic, variant allele frequency: 0.4786 (NCI-PDMR=8847).

HLA typing

Source: NCI-PDMR=8847

Class I
HLA-A	A*02:01,03:01
HLA-B	B*07:02,13:02
HLA-C	C*06:02,07:02

Disease

Melanoma (NCIt: C3224)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Female

Age at sampling

67Y