Cellosaurus cell line BXdmg1 (CVCL

Cellosaurus BXdmg1 (CVCL_F4BV)

Entry history
Cell line name	BXdmg1
Accession	CVCL_F4BV
Resource Identification Initiative	To cite this cell line use: BXdmg1 (RRID:CVCL_F4BV)
Comments	Characteristics: Displays H3F3A (Histone H3.3) K27M mutation. Retains wild-type IDH1, IDH2 and HIST1H3B. EGFR is not amplified. Characteristics: Shows ATRX and P53 expression by immunohistochemistry. Characteristics: Displays adherent growth. Karyotypic information: No 1p36 or 19q13 deletion. Miscellaneous: Sex of donor and karyotypic information from personal communication of Hagedorn, Martin. Derived from site: In situ; Brain, midline region; UBERON=UBERON_0000955.
Sequence variations	Mutation; HGNC; HGNC:4764; H3-3A; Simple; p.Lys28Met (c.83A>T) (H3.3K27M); ClinVar=VCV000376435; Zygosity=Unspecified (PubMed=35300150).
Disease	Diffuse Midline Glioma, H3 K27M-Mutant (NCIt: C129309) Diffuse midline glioma, H3 K27-altered (ORDO: Orphanet_723358)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Female
Age at sampling	Age unspecified
Category	Cancer cell line
Publications	PubMed=35300150; DOI=10.1093/noajnl/vdac018; PMCID=PMC8923007 Farah Rahal, Caroline Capdevielle, Benoit Rousseau, Julien Izotte, Jean-William Dupuy, David Cappellen, Guillaume Chotard, Melissa Menard, Justine Charpentier, Vincent Jecko, Charline Caumont ...Show all 14 authors... , Edouard Gimbert, Christophe F. Grosset, Martin Hagedorn; Show fewer authors An EZH2 blocker sensitizes histone mutated diffuse midline glioma to cholesterol metabolism inhibitors through an off-target effect. Neurooncol. Adv. 4:vdac018.1-vdac018.13(2022)
Entry creation	25-Jun-2026
Last entry update	25-Jun-2026
Version number	1