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Cellosaurus C6/36-HE8-Act::Cas9-2A-Neo (CVCL_F1ZQ)

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Cell line name C6/36-HE8-Act::Cas9-2A-Neo
Synonyms C6-36-HE8-Act::Cas9-2A-Neo
Accession CVCL_F1ZQ
Resource Identification Initiative To cite this cell line use: C6/36-HE8-Act::Cas9-2A-Neo (RRID:CVCL_F1ZQ)
Comments Group: Insect cell line.
Characteristics: Modified using a Minos mediated integration cassette (MiMIC) to deliver a recombination-mediated cassette (RMCE) acceptor, to add a docking site for recombination via the bacteriophage FC31 integrase.
Characteristics: A N-3xFLAG-spCas9-T2A-Neo construct was integrated in the Act5C locus (PubMed=34819517).
Genetic integration: Method=Transfection; Gene=FPbase; ZERB6; mCherry (Note=Red fluorescent protein derived from drFP583 (dsRed)).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transfection; Gene=UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9.
Species of origin Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta) (NCBI Taxonomy: 7160)
Hierarchy Parent: CVCL_B3N5 (C6/36-HE8)
Sex of cell Sex unspecified
Age at sampling Neonate larva
Category Spontaneously immortalized cell line
Publications

PubMed=34819517; DOI=10.1038/s41467-021-27129-3; PMCID=PMC8613219
Raghuvir Viswanatha, Enzo Mameli, Jonathan Rodiger, Pierre Merckaert, Fabiana Feitosa-Suntheimer, Tonya M. Colpitts, Stephanie E. Mohr, Yanhui Hu, Norbert Perrimon;
Bioinformatic and cell-based tools for pooled CRISPR knockout screening in mosquitos.
Nat. Commun. 12:6825-6825(2021)

Cross-references
Cell line collections (Providers) DGRC; 363
Cell line databases/resources FlyBase_Cell_line; FBtc0000363
Entry history
Entry creation31-Mar-2026
Last entry update31-Mar-2026
Version number1