| Cell line name |
CCRF-CEM C7 3R43 |
|---|
| Synonyms |
CEM-3R43; 3R43 |
|---|
| Accession |
CVCL_F1W6 |
|---|
| Resource Identification Initiative |
To cite this cell line use: CCRF-CEM C7 3R43 (RRID:CVCL_F1W6) |
|---|
| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_41879; Dexamethasone.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084. |
|---|
| Sequence variations |
- Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
- Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
|
|---|
| Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_6825 (CCRF-CEM C7) |
|---|
| Sex of cell |
Female |
|---|
| Age at sampling |
3Y11M |
|---|
| Category |
Cancer cell line |
|---|
| Publications | PubMed=6965106; DOI=10.1128/mcb.1.6.512-521.1981; PMCID=PMC369694
Jeffrey M. Harmon, E. Brad Thompson;
Isolation and characterization of dexamethasone-resistant mutants from human lymphoid cell line CEM-C7.
Mol. Cell. Biol. 1:512-521(1981) PubMed=1972702; DOI=10.1007/BF02624204
David G. Chilton, Betty H. Johnson, Laurence Danel-Moore, Simon Kawa, E. Brad Thompson;
Increased glucocorticoid responsiveness of CD4+ T-cell clonal lines grown in serum-free media.
In Vitro Cell. Dev. Biol. 26:561-570(1990) |
|---|
| Entry history |
|---|
| Entry creation | 27-Nov-2025 |
|---|
| Last entry update | 27-Nov-2025 |
|---|
| Version number | 1 |
|---|
