Cellosaurus cell line HyCyte NCI-H1975 KO-hTP53 (CVCL

Cross-references
Cell line name	HyCyte NCI-H1975 KO-hTP53
Synonyms	hTP53 knockout NCI-H1975
Accession	CVCL_F1S9
Resource Identification Initiative	To cite this cell line use: HyCyte NCI-H1975 KO-hTP53 (RRID:CVCL_F1S9)
Comments	Population: Caucasian. Doubling time: 36-48 hours (Hysigen=CGKO-M3068). Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:11998; TP53. Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations	Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Gly118Asp (c.353G>A); ClinVar=VCV000156446; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease	Lung adenocarcinoma (NCIt: C3512)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_1511 (NCI-H1975)
Sex of cell	Female
Age at sampling	Age unspecified
Category	Cancer cell line
Cell line collections (Providers)	Hysigen; CGKO-M3068
Entry history
Entry creation	27-Nov-2025
Last entry update	27-Nov-2025
Version number	1