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Cellosaurus HT809-TH-tdTomato (CVCL_F1KW)

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Cell line name HT809-TH-tdTomato
Accession CVCL_F1KW
Resource Identification Initiative To cite this cell line use: HT809-TH-tdTomato (RRID:CVCL_F1KW)
Comments Population: Jewish; Ashkenazi.
Characteristics: Using CRISPR/Cas9 a P2-tdTomato constructs was inserted at the C-terminus of one allele of TH. This allows dopaminergic neurons differentiated from this cell line to express tdTomato and be readily identified (PubMed=40667145).
Genetic integration: Method=CRISPR/Cas9; Gene=FPbase; PGG5S; tdTomato (Note=Bright red fluorescent protein derived from drFP583 (DsRed)).
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
Disease Gaucher disease (NCIt: C61268)
Parkinson disease (NCIt: C26845)
Gaucher disease (ORDO: Orphanet_355)
Hereditary late-onset Parkinson disease (ORDO: Orphanet_411602)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_F1KV (HT809)
Children:
CVCL_F1KX (HT809-TH-tdTomato-LysoIP-MitoIP)
Sex of cell Male
Age at sampling 65Y
Category Induced pluripotent stem cell
Publications

PubMed=40667145; DOI=10.1101/2025.06.23.661126; PMCID=PMC12262256
Chase Chen, Charis Ma, Richard Sam, Jens Lichtenberg, Tiffany C. Chen, Ying Hao, Zi-Ywi Li, Isabelle Kowal, Katherine M. Andersh, Yue Andy Qi, Gani Perez ...Show all 21 authors... , Ellen Hertz, Yan Li, Darian Williams, Mark J. Henderson, Morgan Park, Xun-Tian Jiang, Pilar Alvarez Jerez, Cornelis Blauwendraat, Ellen Sidransky, Yu Chen; Show fewer authors
Bidirectional regulation of glycoprotein nonmetastatic melanoma protein B by beta-glucocerebrosidase deficiency in GBA1 isogenic dopaminergic neurons from a patient with Gaucher disease and parkinsonism.
bioRxiv 2025:06.23.661126-06.23.661126(2025)

Entry history
Entry creation27-Nov-2025
Last entry update27-Nov-2025
Version number1