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Cellosaurus DT40-TDP2(-/-/-) hTDP2 (CVCL_F1KQ)

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Cell line name DT40-TDP2(-/-/-) hTDP2
Synonyms TDP2-/-/- hTDP2
Accession CVCL_F1KQ
Resource Identification Initiative To cite this cell line use: DT40-TDP2(-/-/-) hTDP2 (RRID:CVCL_F1KQ)
Comments Group: Bird cell line.
Knockout cell: Method=Targeted integration; CGNC; 10219; TDP2.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:17768; TDP2.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: NCBI_TaxID; 11864; Avian leukosis virus (ALV).
Cell type: B-cell; CL=CL_0000236.
Disease Chicken bursal lymphoma (NCIt: C134556)
Species of origin Gallus gallus (Chicken) (NCBI Taxonomy: 9031)
Breed/subspecies: Hy-Line SC.
Hierarchy Parent: CVCL_F1BX (DT40-TDP2(-/-/-) clone 8)
Sex of cell Female
Age at sampling 1D
Category Cancer cell line
Publications

PubMed=21030584; DOI=10.1074/jbc.M110.181016; PMCID=PMC3012998
Zhi-Hong Zeng, Felipe Cortes-Ledesma, Sherif Faruk El-Khamisy, Keith W. Caldecott;
TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage.
J. Biol. Chem. 286:403-409(2011)

Entry history
Entry creation27-Nov-2025
Last entry update27-Nov-2025
Version number1