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Cellosaurus (CVCL_F1KM)

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Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
Sequence variations
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (PubMed=24035680).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg158His (c.473G>A); ClinVar=VCV000141963; Zygosity=Homozygous (Cosmic-CLP=753552; DepMap=ACH-002235).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.74
Native American0
East Asian, North71.8
East Asian, South26.84
South Asian0
European, North0
European, South0.61
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Gallus gallus (Chicken) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 48Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP=753552

Markers:
AmelogeninX,Y
CSF1PO12
D13S3178,10
D16S53910,12
D5S81811
D7S8209,11
TH019
TPOX8,9
vWA16,17

Run an STR similarity search on this cell line
Publications


Charles Weissmann;
A novel, quantitative bioassay for type I interferon using a recombinant indicator cell line.
Biotechnology (N.Y.) 8:1263-1267(1990)


Helmut Gadner, Peter F. Ambros;
Chromosomal regions involved in the pathogenesis of osteosarcomas.
Genes Chromosomes Cancer 28:329-336(2000)


Siegfried Scherneck;
Identification of microsatellite instability and mismatch repair gene mutations in breast cancer cell lines.
Genes Chromosomes Cancer 37:29-35(2003)


Paula D. Bos, Xiang H.-F. Zhang, Cristina Nadal, Wei-Ping Shu, Roger R. Gomis, Don X. Nguyen, Andy J. Minn, Marc Joan van de Vijver, William Levi Gerald, John A. Foekens, Joan Massague;
Genes that mediate breast cancer metastasis to the brain.
Nature 459:1005-1009(2009)


Agnes-Laurence Chenine, Victoria R. Polonis, Michael A. Eller, Lindsay Wieczorek, Christina Ochsenbauer-Jambor, John C. Kappes, Stephen Perfetto, David Charles Montefiori, Nelson L. Michael, Jerome Hahn Kim;
Detection of HIV-1 neutralizing antibodies in a human CD4(+)/CXCR4(+)/CCR5(+) T-lymphoblastoid cell assay system.
PLoS ONE 8:e77756.1-e77756.13(2013)


Yasuhiro Takashima, Ge Guo, Remco Loos, Jennifer Nichols, Gabriella Ficz, Felix Krueger, David Oxley, Fatima Santos, James Clarke, William Mansfield, Wolf Reik ...Show all 13 authors... , Paul Bertone, Austin Gerard Smith; Show fewer authors
Resetting transcription factor control circuitry toward ground-state pluripotency in human.
Cell 158:1254-1269(2014)



literature.
Cancer Res. 77:2784-2788(2017)




Cancer Cell 33:386-400.e5(2018)



apoptosis, which are enhanced by autophagy inhibition.
Eur. J. Surg. Oncol. 48:1527-1535(2022)

Cross-references
Cell line databases/resources Cosmic-CLP; 753552
DepMap; ACH-002235
LINCS_LDP; LCL-1706
Chemistry resources GDSC; 753552
PharmacoDB; DSH1_308_2019
PubChem_Cell_line; CVCL_1182
Encyclopedic resources Wikidata; Q54831450
Gene expression databases GEO; GSM1669744
Polymorphism and mutation databases Cosmic; 1285991
Cosmic; 2050441
Cosmic; 2057445
Cosmic; 2444226
Cosmic; 2685943
IARC_TP53; 21312
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number38