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Cellosaurus MB073 (CVCL_F1J1)

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Cell line name MB073
Accession CVCL_F1J1
Resource Identification Initiative To cite this cell line use: MB073 (RRID:CVCL_F1J1)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=MGI; MGI:88357; Cdk4.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Thigh, quadriceps skeletal muscle; UBERON=UBERON_0004498.
Cell type: Myoblast; CL=CL_0000056.
Sequence variations
  • Gene deletion; HGNC; HGNC:50800; DUX4; Zygosity=Heterozygous; Note=D4Z4 repeat contraction (to 8 repeats) (PubMed=29533181).
Disease Facioscapulohumeral muscular dystrophy 1 (NCIt: C172704)
Facioscapulohumeral dystrophy (ORDO: Orphanet_269)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 40Y
Category Telomerase immortalized cell line
Publications

PubMed=29533181; DOI=10.7554/eLife.31023; PMCID=PMC5849414
Amy E. Campbell, Sean C. Shadle, Sujatha Jagannathan, Jong-Won Lim, Rebecca Resnick, Rabi Nabil Tawil, Silvere Maria van der Maarel, Stephen Justice Tapscott;
NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins.
eLife 7:e31023.1-e31023.27(2018)

Entry history
Entry creation27-Nov-2025
Last entry update27-Nov-2025
Version number1