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Cellosaurus MCF-7/HRG-T5 (CVCL_F1C4)

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Cell line name MCF-7/HRG-T5
Synonyms MCF-7/T5
Accession CVCL_F1C4
Resource Identification Initiative To cite this cell line use: MCF-7/HRG-T5 (RRID:CVCL_F1C4)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:7997; NRG1 (Note=Isoform beta-2).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=9563896
Lyndsay N. Harris, Li Yang, Careen K. Tang, Da-Jun Yang, Ruth Lupu;
Induction of sensitivity to doxorubicin and etoposide by transfection of MCF-7 breast cancer cells with heregulin beta-2.
Clin. Cancer Res. 4:1005-1012(1998)

Entry history
Entry creation27-Nov-2025
Last entry update27-Nov-2025
Version number1