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Cellosaurus M-2 (CVCL_F0T8)

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Cell line name M-2
Accession CVCL_F0T8
Resource Identification Initiative To cite this cell line use: M-2 (RRID:CVCL_F0T8)
Comments Doubling time: ~24 hours (PubMed=5225150).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Donor information: Established from a patient suffering from chronic myelogenous leukemia, BCR-ABL1 positive.
Caution: As it is indicated in PubMed=5225151 that this cell line harbors an herpes-like virus and that many leukemia cell lines from this period were later found to be EBV-transformed cell lines, we have annotated it as such.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 57Y
Category Transformed cell line
Publications

PubMed=5225150; DOI=10.1093/jnci/37.6.753
Linda S. Lucas, Jacqueline Whang-Peng, Joe Hin Tjio, Robert A. Manaker, Victor H. Zeve;
Continuous cell culture from a patient with chronic myelogenous leukemia. I. Propagation and presence of Philadelphia chromosome.
J. Natl. Cancer Inst. 37:753-759(1966)

PubMed=5225151; DOI=10.1093/jnci/37.6.761
Victor H. Zeve, Linda S. Lucas, Robert A. Manaker;
Continuous cell culture from a patient with chronic myelogenous leukemia. II. Detection of a herpes-like virus by electron microscopy.
J. Natl. Cancer Inst. 37:761-773(1966)

Entry history
Entry creation27-Nov-2025
Last entry update27-Nov-2025
Version number1