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Cellosaurus HEK293 TDP-43 (CVCL_F0R9)

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Cell line name HEK293 TDP-43
Accession CVCL_F0R9
Resource Identification Initiative To cite this cell line use: HEK293 TDP-43 (RRID:CVCL_F0R9)
Comments Characteristics: Using a pcDNA4/TO/myc-His based construct TARDBP/TDP-43 was transfected and its expression is regulated by doxycycline (PubMed=31100073).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:11571; TARDBP (Note=With a C-terminal mycHis6 tag).
Genetic integration: Method=Transfection; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
Genetic integration: Method=Transfection; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
Transformant: NCBI_TaxID; 28285; Human adenovirus C serotype 5.
Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_D585 (T-REx-293)
Sex of cell Female
Age at sampling Fetus
Category Transformed cell line
Publications

PubMed=31100073; DOI=10.1371/journal.pgen.1007947; PMCID=PMC6524796
Peng Wang, Jian-Wen Deng, Jie Dong, Jiang-Hong Liu, Eileen H. Bigio, Marek Marsel Mesulam, Tao Wang, Lei Sun, Li Wang, Alan Yueh-Luen Lee, Warren A. McGee ...Show all 15 authors... , Xiao-Ping Chen, Kazuo Fushimi, Li Zhu, Jane Ying Wu; Show fewer authors
TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response.
PLoS Genet. 15:e1007947.1-e1007947.32(2019)

Entry history
Entry creation27-Nov-2025
Last entry update27-Nov-2025
Version number1