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Cellosaurus U2OS:GFP-parkin (CVCL_F0QH)

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Cell line name U2OS:GFP-parkin
Accession CVCL_F0QH
Resource Identification Initiative To cite this cell line use: U2OS:GFP-parkin (RRID:CVCL_F0QH)
Comments From: Screaton, Robert A.; Sunnybrook Research Institute; Toronto; Canada.
Population: Caucasian.
Genetic integration: Method=Transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:8607; PRKN.
Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Sequence variations
  • Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0042 (U2OS)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=24446486; DOI=10.1002/embj.201385902; PMCID=PMC3989637
Gian-Luca McLelland, Vincent Soubannier, Carol Xiu-Qing Chen, Heidi M. McBride, Edward A. Fon;
Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control.
EMBO J. 33:282-295(2014)

Entry history
Entry creation27-Nov-2025
Last entry update27-Nov-2025
Version number1