| Cell line name |
LNCaPR |
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| Accession |
CVCL_F0L9 |
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| Resource Identification Initiative |
To cite this cell line use: LNCaPR (RRID:CVCL_F0L9) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_4672; Docetaxel anhydrous (Taxotere).
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056. |
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| Sequence variations |
- Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
- Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
|
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| Disease |
Prostate carcinoma (NCIt: C4863) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0395 (LNCaP) |
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| Sex of cell |
Male |
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| Age at sampling |
50Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=33799432; DOI=10.3390/cancers13061290; PMCID=PMC7998254
Thiago S. Lima, Diego Iglesias-Gato, Luciano de Oliveira Souza, Jan Stenvang, Diego S. Lima, Martin Andreas Roder, Klaus Brasso, Jose M.A. Moreira;
Molecular profiling of docetaxel-resistant prostate cancer cells identifies multiple mechanisms of therapeutic resistance.
Cancers (Basel) 13:1290.1-1290.19(2021) |
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| Entry history |
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| Entry creation | 14-Aug-2025 |
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| Last entry update | 14-Aug-2025 |
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| Version number | 1 |
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