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Cellosaurus LNCaP C4-2BR (CVCL_F0L8)

[Text version]
Cell line name LNCaP C4-2BR
Synonyms C4-2BR
Accession CVCL_F0L8
Resource Identification Initiative To cite this cell line use: LNCaP C4-2BR (RRID:CVCL_F0L8)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_4672; Docetaxel anhydrous (Taxotere).
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Sequence variations
  • Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4784 (LNCaP C4-2B)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
Publications

PubMed=33799432; DOI=10.3390/cancers13061290; PMCID=PMC7998254
Thiago S. Lima, Diego Iglesias-Gato, Luciano de Oliveira Souza, Jan Stenvang, Diego S. Lima, Martin Andreas Roder, Klaus Brasso, Jose M.A. Moreira;
Molecular profiling of docetaxel-resistant prostate cancer cells identifies multiple mechanisms of therapeutic resistance.
Cancers (Basel) 13:1290.1-1290.19(2021)

Entry history
Entry creation14-Aug-2025
Last entry update14-Aug-2025
Version number1