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Cellosaurus LNCaP C4-2 AR-V7 (CVCL_F0L4)

[Text version]
Cell line name LNCaP C4-2 AR-V7
Synonyms C4-2 AR-V7
Accession CVCL_F0L4
Resource Identification Initiative To cite this cell line use: LNCaP C4-2 AR-V7 (RRID:CVCL_F0L4)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:644; AR (Note=Isoform ARv7).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Sequence variations
  • Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4782 (LNCaP C4-2)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
Publications

PubMed=24740322; DOI=10.1158/1078-0432.CCR-13-3296; PMCID=PMC4058390
Cheng-Fei Liu, Wei Lou, Ye-Zi Zhu, Nagalakshmi Nadiminty, Chad T. Schwartz, Christopher P. Evans, Allen C. Gao;
Niclosamide inhibits androgen receptor variants expression and overcomes enzalutamide resistance in castration-resistant prostate cancer.
Clin. Cancer Res. 20:3198-3210(2014)

Entry history
Entry creation14-Aug-2025
Last entry update14-Aug-2025
Version number1