Cellosaurus cell line HeLa rCD4 m6 (CVCL

Cellosaurus HeLa rCD4 m6 (CVCL_F0JM)

Entry history
Cell line name	HeLa rCD4 m6
Synonyms	HeLa m6
Accession	CVCL_F0JM
Resource Identification Initiative	To cite this cell line use: HeLa rCD4 m6 (RRID:CVCL_F0JM)
Comments	Population: African American. Genetic integration: Method=Transfection; Gene=RGD; 2306; Cd4 (Note=With p.Gly33-Thr62 replaced by equivalent region of human CD4). Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo. Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18). Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease	Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0030 (HeLa)
Sex of cell	Female
Age at sampling	30Y6M
Category	Cancer cell line
Publications	PubMed=8459222; DOI=10.1084/jem.177.4.949; PMCID=PMC2190986 James H.M. Simon, Chamorro Somoza, Gerard Alphonse Schockmel, Matthew Collin, Simon J. Davis, Alan Frederick Williams, William S. James; A rat CD4 mutant containing the gp120-binding site mediates human immunodeficiency virus type 1 infection. J. Exp. Med. 177:949-954(1993) PubMed=8995673; DOI=10.1128/JVI.71.2.1476-1484.1997; PMCID=PMC191204 James H.M. Simon, Philip A. Stumbles, Nathalie Signoret, Chamorro Somoza, Michael Joseph Puklavec, Quentin James Sattentau, Alan Neil Barclay, William S. James; Role of CD4 epitopes outside the gp120-binding site during entry of human immunodeficiency virus type 1. J. Virol. 71:1476-1484(1997)
Entry creation	14-Aug-2025
Last entry update	14-Aug-2025
Version number	1