Cellosaurus logo
expasy logo

Cellosaurus LoKe (CVCL_F001)

[Text][XML][JSON]
Cell line name LoKe
Accession CVCL_F001
Resource Identification Initiative To cite this cell line use: LoKe (RRID:CVCL_F001)
Comments Doubling time: 4 days (PubMed=30873613).
Transformant: NCBI_TaxID; 493803; Merkel cell polyomavirus (MCPyV).
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Disease Merkel cell carcinoma (NCIt: C9231)
Cutaneous neuroendocrine carcinoma (ORDO: Orphanet_79140)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 64Y
Category Cancer cell line
STR profile Source(s): PubMed=30873613

Markers:
AmelogeninX,Y
CSF1PO12
D3S135816
D5S81812
D7S82010
D8S117911,12
D13S31711,13
D16S53911
D18S5112,24
D21S1128.2
FGA22,25
Penta D12,13
Penta E10,11
TH019.3
TPOX8,11
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=22363598; DOI=10.1371/journal.pone.0031255; PMCID=PMC3281946
Christian Hafner, Roland Houben, Anne Baeurle, Cathrin Ritter, David Schrama, Michael Landthaler, Jurgen C. Becker;
Activation of the PI3K/AKT pathway in Merkel cell carcinoma.
PLoS ONE 7:e31255.1-e31255.8(2012)

PubMed=23563200; DOI=10.1038/jid.2013.169
Roland Houben, Christina Dreher, Sabrina Angermeyer, Andreas Borst, Jochen Sven Utikal, Sebastian Haferkamp, Wiebke K. Peitsch, David Schrama, Sonja Hesbacher;
Mechanisms of p53 restriction in Merkel cell carcinoma cells are independent of the Merkel cell polyoma virus T antigens.
J. Invest. Dermatol. 133:2453-2460(2013)

PubMed=27121059; DOI=10.18632/oncotarget.8793; PMCID=PMC5078066
Sonja Hesbacher, Lisa Pfitzer, Katharina Wiedorfer, Sabrina Angermeyer, Andreas Borst, Sebastian Haferkamp, Claus-Jurgen Scholz, Marion Wobser, David Schrama, Roland Houben;
RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells.
Oncotarget 7:32956-32968(2016)

PubMed=30873613; DOI=10.1002/ijc.32280
David Schrama, Eva-Maria Sarosi, Christian Adam, Cathrin Ritter, Ulrike Kaemmerer, Eva Klopocki, Eva-Maria Konig, Jochen Sven Utikal, Jurgen C. Becker, Roland Houben;
Characterization of six Merkel cell polyomavirus-positive Merkel cell carcinoma cell lines: integration pattern suggest that large T antigen truncating events occur before or during integration.
Int. J. Cancer 145:1020-1032(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_F001
Encyclopedic resources Wikidata; Q54902884
Gene expression databases GEO; GSM1904843
Polymorphism and mutation databases Cosmic; 1699821
Progenetix; CVCL_F001
Entry history
Entry creation22-Oct-2012
Last entry update10-Apr-2025
Version number14