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Cellosaurus LoKe (CVCL_F001)

[Text version]
Cell line name LoKe
Accession CVCL_F001
Resource Identification Initiative To cite this cell line use: LoKe (RRID:CVCL_F001)
Comments Doubling time: 4 days (PubMed=30873613).
Transformant: NCBI_TaxID; 493803; Merkel cell polyomavirus (MCPyV).
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Disease Merkel cell carcinoma (NCIt: C9231)
Cutaneous neuroendocrine carcinoma (ORDO: Orphanet_79140)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 64Y
Category Cancer cell line
STR profile Source(s): PubMed=30873613

Markers:
AmelogeninX,Y
CSF1PO12
D3S135816
D5S81812
D7S82010
D8S117911,12
D13S31711,13
D16S53911
D18S5112,24
D21S1128.2
FGA22,25
Penta D12,13
Penta E10,11
TH019.3
TPOX8,11
vWA18

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Publications

PubMed=22363598; DOI=10.1371/journal.pone.0031255; PMCID=PMC3281946
Hafner C., Houben R., Baeurle A., Ritter C., Schrama D., Landthaler M., Becker J.C.
Activation of the PI3K/AKT pathway in Merkel cell carcinoma.
PLoS ONE 7:e31255.1-e31255.8(2012)

PubMed=23563200; DOI=10.1038/jid.2013.169
Houben R., Dreher C., Angermeyer S., Borst A., Utikal J.S., Haferkamp S., Peitsch W.K., Schrama D., Hesbacher S.
Mechanisms of p53 restriction in Merkel cell carcinoma cells are independent of the Merkel cell polyoma virus T antigens.
J. Invest. Dermatol. 133:2453-2460(2013)

PubMed=27121059; DOI=10.18632/oncotarget.8793; PMCID=PMC5078066
Hesbacher S., Pfitzer L., Wiedorfer K., Angermeyer S., Borst A., Haferkamp S., Scholz C.-J., Wobser M., Schrama D., Houben R.
RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells.
Oncotarget 7:32956-32968(2016)

PubMed=30873613; DOI=10.1002/ijc.32280
Schrama D., Sarosi E.-M., Adam C., Ritter C., Kaemmerer U., Klopocki E., Konig E.-M., Utikal J.S., Becker J.C., Houben R.
Characterization of six Merkel cell polyomavirus-positive Merkel cell carcinoma cell lines: integration pattern suggest that large T antigen truncating events occur before or during integration.
Int. J. Cancer 145:1020-1032(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_F001
Encyclopedic resources Wikidata; Q54902884
Gene expression databases GEO; GSM1904843
Polymorphism and mutation databases Cosmic; 1699821
Progenetix; CVCL_F001
Entry history
Entry creation22-Oct-2012
Last entry update10-Apr-2025
Version number14